Abstract
This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.
Current Pharmaceutical Design
Title:Targeting Cancer Cells with Photoactive Silica Nanoparticles
Volume: 22 Issue: 39
Author(s): Wioleta Borzęcka, Tito Trindade, Tomás Torres and João Tomé
Affiliation:
Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.
Abstract: This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
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Cite this article as:
Borzęcka Wioleta, Trindade Tito, Torres Tomás and Tomé João, Targeting Cancer Cells with Photoactive Silica Nanoparticles, Current Pharmaceutical Design 2016; 22 (39) . https://dx.doi.org/10.2174/1381612822666160614083804
DOI https://dx.doi.org/10.2174/1381612822666160614083804 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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