The Connections Among Autophagy, Inflammasome and Mitochondria

Title:The Connections Among Autophagy, Inflammasome and Mitochondria

Volume: 18 Issue: 9

Author(s): Isabel de Lavera, Ana Delgado Pavon, Marina Villanueva Paz, Manuel Oropesa-Avila, Mario de la Mata, Elizabet Alcocer-Gomez, Juan Garrido-Maraver, David Cotan, Monica Alvarez-Cordoba and Jose A. Sanchez-Alcazar*

Affiliation:

• Centro Andaluz de Biología del Desarrollo [CABD]. Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas. Carretera de Utrera Km 1, Sevilla 41013,Spain

Keywords: Autophagy, cytokines, inflammasome, mitochondria, NLRP3, ROS.

Abstract: Background: The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions.

Objective: In this review, we briefly describe the relationship between autophagy and inflammasome activation. The central role that mitochondria play in both cellular processes is also discussed.

Conclusion: Inflammasome and autophagy often modulate each other by common inhibitory mechanisms that are controlled by different input pathways. Thus, inflammasome components coordinate autophagy and autophagy regulates inflammasome activation, making the balance between both processes a fundamental player in cellular homeostasis.

Cite this article as:

de Lavera Isabel, Pavon Delgado Ana, Paz Villanueva Marina, Oropesa-Avila Manuel, de la Mata Mario, Alcocer-Gomez Elizabet, Garrido-Maraver Juan, Cotan David, Alvarez-Cordoba Monica and Sanchez-Alcazar A. Jose*, The Connections Among Autophagy, Inflammasome and Mitochondria, Current Drug Targets 2017; 18 (9) . https://dx.doi.org/10.2174/1389450117666160527143143

DOI https://dx.doi.org/10.2174/1389450117666160527143143	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592