自噬，免疫细胞和线粒体之间的联系

Title:The Connections Among Autophagy, Inflammasome and Mitochondria

Volume: 18 Issue: 9

关键词: 自噬，细胞因子，炎性体，线粒体，NLRP3，ROS

摘要: Background: The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions.

Objective: In this review, we briefly describe the relationship between autophagy and inflammasome activation. The central role that mitochondria play in both cellular processes is also discussed.

Conclusion: Inflammasome and autophagy often modulate each other by common inhibitory mechanisms that are controlled by different input pathways. Thus, inflammasome components coordinate autophagy and autophagy regulates inflammasome activation, making the balance between both processes a fundamental player in cellular homeostasis.

Cite this article as:

The Connections Among Autophagy, Inflammasome and Mitochondria, Current Drug Targets 2017; 18 (9) . https://dx.doi.org/10.2174/1389450117666160527143143

DOI https://dx.doi.org/10.2174/1389450117666160527143143	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592