Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note

Title:Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note

Volume: 13 Issue: 1

Author(s): Arun K. Mishra, Pragya Yadav, Niharika Lal, Arvind Kumar and Amrita Mishra

Affiliation:

Keywords: ATP, biosynthesis, coenzyme Q₁₀, pharmacokinetics, pharmacology, therapeutic effects.

Abstract: Introduction: Extensive research over the past years has reflected that Coenzyme Q₁₀ (abbreviated as CoQ₁₀), is lipophilic, similar to vitamins, present in eukaryotic cells, acts as the chief element in the electron transport chain and is involved in aerobic respiration, producing energy (ATP). Therefore, CoQ₁₀ is required in all energy based processes in the heart, including heart muscle contraction and the functioning of ATP regulated membrane channels.

Chemistry and Pharmacological Properties: An important property of CoQ₁₀ includes membranestabilizing properties, which are mainly due to the free radical scavenging effect of CoQ₁₀. Absorption and uptake mechanism of CoQ₁₀ follows the same pattern as lipids (such as vitamin E). Administration of CoQ₁₀ in hypertensive patients results in significant reduction of systolic and diastolic blood pressure without affecting cardiac output or stroke volume. In addition, it protects the retinal cells from Sun radiations by neutralizing free radicals. Therefore, it can be said that CoQ₁₀ enhances the mitochondrial function of cell to rejuvenate the skin.

Conclusion: The present review is devoted towards better understanding of the chemistry, including biosynthesis and biological attributes of CoQ₁₀. In addition, it focuses the disease specific indications and the prophylactic and therapeutic nutraceutical qualities of CoQ₁₀.

Cite this article as:

Mishra K. Arun, Yadav Pragya, Lal Niharika, Kumar Arvind and Mishra Amrita, Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note, Current Bioactive Compounds 2017; 13 (1) . https://dx.doi.org/10.2174/1573407212666160519143123

DOI https://dx.doi.org/10.2174/1573407212666160519143123	Print ISSN 1573-4072
Publisher Name Bentham Science Publisher	Online ISSN 1875-6646