Abstract
The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Current Proteomics
Title:Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis
Volume: 13 Issue: 1
Author(s): Jose Antonio O'Daly
Affiliation:
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Abstract: The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
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Cite this article as:
O'Daly Antonio Jose, Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis, Current Proteomics 2016; 13 (1) . https://dx.doi.org/10.2174/1570164613666160414115005
DOI https://dx.doi.org/10.2174/1570164613666160414115005 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
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