Abstract
Psoriasis is a common skin disorder characterized by hyper proliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, immune system and its interaction with nervous system have been postulated and investigated as the underlying mechanism. The interaction between these two systems through cholinergic anti-inflammatory pathway and also endocannabinoid system, may suggest cannabinoids as potential addition to antipsoriatic armamentarium.
Keywords: Psoriasis, immunomodulation, cannabidiol, endocannabinoids, vagal nerve stimulation.
Graphical Abstract
Current Clinical Pharmacology
Title:Cannabis for Refractory Psoriasis—High Hopes for a Novel Treatment and a Literature Review
Volume: 11 Issue: 2
Author(s): Nima Derakhshan and Mahboubeh Kazemi
Affiliation:
Keywords: Psoriasis, immunomodulation, cannabidiol, endocannabinoids, vagal nerve stimulation.
Abstract: Psoriasis is a common skin disorder characterized by hyper proliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, immune system and its interaction with nervous system have been postulated and investigated as the underlying mechanism. The interaction between these two systems through cholinergic anti-inflammatory pathway and also endocannabinoid system, may suggest cannabinoids as potential addition to antipsoriatic armamentarium.
Export Options
About this article
Cite this article as:
Derakhshan Nima and Kazemi Mahboubeh, Cannabis for Refractory Psoriasis—High Hopes for a Novel Treatment and a Literature Review, Current Clinical Pharmacology 2016; 11 (2) . https://dx.doi.org/10.2174/1574884711666160511150126
DOI https://dx.doi.org/10.2174/1574884711666160511150126 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
Related Articles
-
Cranberry as Promising Natural Source of Potential Anticancer Agents: Current Evidence and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry Lipid Rafts, Endoplasmic Reticulum and Mitochondria in the Antitumor Action of the Alkylphospholipid Analog Edelfosine
Anti-Cancer Agents in Medicinal Chemistry HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting
Current Pharmaceutical Design Cellular and Physiological Effects of Short-Chain Fatty Acids
Mini-Reviews in Medicinal Chemistry Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Current Medicinal Chemistry Meet Our Editorial Board Member
Endocrine, Metabolic & Immune Disorders - Drug Targets Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System
Current Pharmaceutical Design Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells
Current Pharmaceutical Design Uteroplacental Circulation and Fetal Vascular Function and Development
Current Vascular Pharmacology Counter-Regulatory Role of Bile Acid Activated Receptors in Immunity and Inflammation
Current Molecular Medicine Synthesis of 2-Methyl N10-Substituted Acridones as Selective Inhibitors of Multidrug Resistance (MDR) Associated Protein in Cancer Cells
Medicinal Chemistry Animal Models of Ejaculatory Behavior
Current Pharmaceutical Design Hepatitis C Virus Proteins as Targets for Drug Development: The Role of Bioinformatics and Modelling
Current Drug Targets Effect of a New Class of Compounds of the Group of Substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction
Current Vascular Pharmacology Structure, Biology, and Therapeutic Implications of Pegylated Interferon Alpha-2b
Current Pharmaceutical Design Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Current Neuropharmacology Chemistry and Structural Evaluation of Different Phospholipase A2 Inhibitors in Arachidonic Acid Pathway Mediated Inflammation and Snake Venom Toxicity
Current Topics in Medicinal Chemistry Low-Cost Anti-HIV Compounds: Potential Application for AIDS Therapy in Developing Countries
Current Pharmaceutical Design Gene Vectors for Cytokine Expression In Vivo
Current Pharmaceutical Design Impact of Dendritic Cells on Vascular Biology
Current Hypertension Reviews