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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Applications of Nuclear Technique to Biological Sciences Labelled Compounds, Radioactive Tracers, and X-Ray Tomography

Author(s): Y. Kobayashi

Volume 16, Issue 24, 2016

Page: [2694 - 2702] Pages: 9

DOI: 10.2174/1568026616666160413134922

Price: $65

Abstract

A radioisotope and its imaging have been powerful tools to explore the mechanism of chemical reaction and the dynamic behavior of trace element in biomolecular science and nuclear medicine. This article reviews some labelled compounds for radiopharmaceuticals in biochemical science and nuclear medicine using short-lived nuclides, the production and applications of “Multitracer” containing carrier-free radionuclides of more than 50 elements and a new radioactive tracer technique coupled with simultaneously imaging of multiple molecules labelled by γ-emitters. In addition, X-ray phase imaging and microscopy technique using synchrotron radiation are introduced.

Keywords: Radioactive tracer, Labelled compounds, Nuclear reaction, Nuclear fragment, Multitracer, Carrier-free, γ-Ray emission imaging (GREI), α-Emitter, Phase-contrast X-ray imaging, Synchrotron radiation.

Graphical Abstract


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