Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity

Title:Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity

Volume: 16 Issue: 16

Author(s): Xiaoke Guo, Weilin Chen, Haopeng Sun and Qidong You

Affiliation:

Keywords: Atrial fibrillation; I_Kur, Kv1.5, Multiple ion channel inhibitor, Nonselective inhibitor, Selective Kv1.5 inhibitor.

Abstract: Atrial fibrillation (AF) is one of the common arrhythmias that threatens human health and brings a huge burden to society. Current treatments of AF possess limited efficacy and considerable risks, so a lot of efforts have been made to develop new AF therapies. Kv1.5 potassium channel is considered as an efficacious and safe therapeutic target of AF for its selective existence in atrium. This review will give a brief profile of Kv1.5 potassium channel and describe the progress of Kv1.5 inhibitors in this decade from nonselective drugs to selective agents. The final section will discuss the advantages and disadvantages between selectivity and non-selectivity.

Cite this article as:

Guo Xiaoke, Chen Weilin, Sun Haopeng and You Qidong, Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity, Current Topics in Medicinal Chemistry 2016; 16 (16) . https://dx.doi.org/10.2174/1568026616666160315142647