5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents

Title:5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents

Volume: 16 Issue: 8

Author(s): Abhishek Thakur, Nirnoy Dan, Soumendranath Bhakat, Venkatesan Jayaprakash and Sugato Banerjee

Affiliation:

Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.

Abstract: In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.

Cite this article as:

Thakur Abhishek, Dan Nirnoy, Bhakat Soumendranath, Jayaprakash Venkatesan and Banerjee Sugato, 5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1871520616666160211124240