Abstract
While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.
Keywords: Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent
Mini-Reviews in Medicinal Chemistry
Title: Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors
Volume: 6 Issue: 5
Author(s): Takayoshi Suzuki and Naoki Miyata
Affiliation:
Keywords: Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent
Abstract: While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.
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Cite this article as:
Suzuki Takayoshi and Miyata Naoki, Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876186
DOI https://dx.doi.org/10.2174/138955706776876186 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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