Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors

Author(s): Takayoshi Suzuki and Naoki Miyata

Volume 6, Issue 5, 2006

Page: [515 - 526] Pages: 12

DOI: 10.2174/138955706776876186

Price: $65

Abstract

While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.

Keywords: Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy