Oxidative and Non-Oxidative Metabolomics of Ethanol

Title:Oxidative and Non-Oxidative Metabolomics of Ethanol

Volume: 17 Issue: 4

Author(s): Ricardo J. Dinis-Oliveira

Affiliation:

Keywords: Biomarkers, ethanol, major metabolites, metabolomics, minor metabolites, non-oxidative, oxidative.

Abstract: Background: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile.

Objective: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites.

Method: An exhaustive literature search was carried out using textual and structural queries for ethanol and related known metabolizing enzymes and metabolites.

Results: The main pathway of metabolism is catalyzed by cytosolic alcohol dehydrogenase, which exhibits multiple isoenzymes and genetic polymorphisms with clinical and forensic implications. Another two oxidative routes, the highly inducible CYP2E1 system and peroxisomal catalase may acquire relevance under specific circumstances. In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide, ethyl sulfate, ethyl phosphate, ethyl nitrite, phosphatidylethanol and fatty acid ethyl esters. These metabolites represent alternative biomarkers since they can be detected several hours or days after ethanol exposure.

Conclusion: It is expected that knowing the metabolomics of ethanol may provide additional insights to better understand the toxicological effects and the variability of dose response.

Cite this article as:

Dinis-Oliveira J. Ricardo, Oxidative and Non-Oxidative Metabolomics of Ethanol, Current Drug Metabolism 2016; 17 (4) . https://dx.doi.org/10.2174/1389200217666160125113806