Abstract
Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.
Keywords: Rho GTPase, ROCK, PAK, IQGAP, oncogenesis, metastasis, MDCK, ubiquitin-proteasome system, cancer
Current Drug Targets
Title: Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis
Volume: 12 Issue: 8
Author(s): Somesh Baranwal and Suresh K. Alahari
Affiliation:
Keywords: Rho GTPase, ROCK, PAK, IQGAP, oncogenesis, metastasis, MDCK, ubiquitin-proteasome system, cancer
Abstract: Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.
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Cite this article as:
Baranwal Somesh and K. Alahari Suresh, Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis, Current Drug Targets 2011; 12 (8) . https://dx.doi.org/10.2174/138945011795906534
DOI https://dx.doi.org/10.2174/138945011795906534 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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