Abstract
Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.
Keywords: Rho GTPase, ROCK, PAK, IQGAP, oncogenesis, metastasis, MDCK, ubiquitin-proteasome system, cancer
Current Drug Targets
Title: Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis
Volume: 12 Issue: 8
Author(s): Somesh Baranwal and Suresh K. Alahari
Affiliation:
Keywords: Rho GTPase, ROCK, PAK, IQGAP, oncogenesis, metastasis, MDCK, ubiquitin-proteasome system, cancer
Abstract: Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.
Export Options
About this article
Cite this article as:
Baranwal Somesh and K. Alahari Suresh, Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis, Current Drug Targets 2011; 12 (8) . https://dx.doi.org/10.2174/138945011795906534
DOI https://dx.doi.org/10.2174/138945011795906534 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetic and Modifying Factors that Determine the Risk of Brain Tumors
Central Nervous System Agents in Medicinal Chemistry The “Gene Cube”: A Novel Approach to Three-dimensional Clustering of Gene Expression Data
Current Bioinformatics The Detrimental Effect of Smoking on Female Fertility and IVF Success
Current Women`s Health Reviews Tumor Stroma as a Target in Cancer
Current Cancer Drug Targets Modulation of P2 Receptors on Pancreatic β-cells by Agonists and Antagonists: A Molecular Target for Type 2 Diabetes Treatment
Current Diabetes Reviews Epidemiology, Clinical Presentation and Treatment of Mucosal Melanoma
Clinical Cancer Drugs Biodegradable Composite Scaffolds: A Strategy to Modulate Stem Cell Behaviour
Recent Patents on Drug Delivery & Formulation Intractable Cancers: The Many Faces of Multidrug Resistance and the Many Targets it Presents for Therapeutic Attack
Current Drug Targets Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines
Current Pharmaceutical Biotechnology Biodistribution and Pharmacokinetics of I-131 Labelled 4- Iodophenylacetic Acid
Current Radiopharmaceuticals Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention
Current Topics in Medicinal Chemistry Bioactive Compounds Containing Benzoxadiazole, Benzothiadiazole, Benzotriazole
Current Bioactive Compounds Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes
Anti-Cancer Agents in Medicinal Chemistry Muscarinic Acetylcholine Receptor-Interacting Proteins (mAChRIPs): Targeting the Receptorsome
Current Drug Targets Safety of Systemic Biologic Agents in the Treatment of Non-malignant Skin Disorders
Current Drug Safety Analysis of miRNAs Targeting 3’UTR of H2AFX Gene: a General <i>in Silico</i> Approach
MicroRNA Recent Advances in the Signal Transduction Targeting of Colorectal Cancer: The Paradigm of Translational Medicine
Current Signal Transduction Therapy Pharmacological Approaches to Targeting Muscarinic Acetylcholine Receptors
Recent Patents on CNS Drug Discovery (Discontinued) Blockers of Voltage-Gated Sodium Channels for the Treatment of Central Nervous System Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Apoptosis and Autophagy Induction As Mechanism of Cancer Prevention by Naturally Occurring Dietary Agents
Current Drug Targets