Antiatherosclerotic and Cardioprotective Effects of Time-Released Garlic Powder Pills

Title:Antiatherosclerotic and Cardioprotective Effects of Time-Released Garlic Powder Pills

Volume: 22 Issue: 2

Author(s): Vasily P. Karagodin, Igor A. Sobenin and Alexander N. Orekhov

Affiliation:

Keywords: Atherosclerosis, coronary heart disease, prevention, treatment, garlic, allicor.

Abstract: Garlic is believed to produce beneficial changes in different cardiovascular risk factors, thus possessing antiatherosclerotic properties. The hypotensive and cholesterol-lowering effects were investigated in two studies in men with mild arterial hypertension and in men with mild hypercholesterolemia. Eight-week treatment resulted in the reduction of both systolic and diastolic blood pressure by 5.2% (P=0.008) and 4.0% (P=0.014), respectively. In hypolipidemic study, the 12-week treatment resulted in a decrease in LDL cholesterol by 11.8% (P=0.002), while HDL cholesterol increased by 11.5% (P=0.013). In men with cerebral atherosclerosis it has been demonstrated that 14-days treatment inhibited ADP-induced platelet aggregation by 25.4% (P<0.05) and increased plasma fibrinolytic activity by 22.4% (P<0.05).

One more study was performed in high-risk patients to evaluate the changes of prognostic cardiovascular risk that was calculated using algorithms derived from Framingham and Muenster Studies. Twelve-months treatment lowered 10-years prognostic risk of CHD by 13.2% in men (P=0.005), and by 7.1% in women (P=0.040). Ten-year prognostic risk of acute myocardial infarction and sudden coronary death was lowered by 26.1% in men (P=0.025).

Cite this article as:

Karagodin P. Vasily, Sobenin A. Igor and Orekhov N. Alexander, Antiatherosclerotic and Cardioprotective Effects of Time-Released Garlic Powder Pills, Current Pharmaceutical Design 2016; 22 (2) . https://dx.doi.org/10.2174/1381612822666151112153351