Abstract
The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels
Letters in Drug Design & Discovery
Title: Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides
Volume: 4 Issue: 3
Author(s): T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara and O. G. Simonova
Affiliation:
Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels
Abstract: The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
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Tolstikova G. T., Bryzgalov O. A., Sorokina V. I., Hvostov V. M., Ratushnyak S. A., Zapara A. T. and Simonova G. O., Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077453
DOI https://dx.doi.org/10.2174/157018007780077453 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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