Abstract
Lamotrigine is an anticonvulsant medication that also has utility in the treatment of bipolar disorder. It has been associated with many side effects, including rashes that can progress to Stevens-Johnson syndrome or toxic epidermal necrolysis. It has also been associated with the development of motor tics, most commonly in the head, neck, and shoulders. We will now present the case of a 45-year-old woman who developed tics that involved the entire left side of her body after her dose of lamotrigine was increased from 200 mg daily (2.0 mg/kg/day) to 225 mg daily (2.3 mg/kg/day). We will review the prior cases of lamotrigine induced tics, and compare them to the circumstances surrounding our patient. We will also discuss the neurobiology of tics and make suggestions to improve the tics, based on the reported cases.
Keywords: Anticonvulsant, bipolar disorder, dopamine, lamotrigine, side effects, tics.
Current Drug Safety
Title:Lamotrigine Induced Whole Body Tics: A Case Report and Literature Review
Volume: 11 Issue: 2
Author(s): Michael B. Centorino, Glenn Catalano and Maria C. Catalano
Affiliation:
Keywords: Anticonvulsant, bipolar disorder, dopamine, lamotrigine, side effects, tics.
Abstract: Lamotrigine is an anticonvulsant medication that also has utility in the treatment of bipolar disorder. It has been associated with many side effects, including rashes that can progress to Stevens-Johnson syndrome or toxic epidermal necrolysis. It has also been associated with the development of motor tics, most commonly in the head, neck, and shoulders. We will now present the case of a 45-year-old woman who developed tics that involved the entire left side of her body after her dose of lamotrigine was increased from 200 mg daily (2.0 mg/kg/day) to 225 mg daily (2.3 mg/kg/day). We will review the prior cases of lamotrigine induced tics, and compare them to the circumstances surrounding our patient. We will also discuss the neurobiology of tics and make suggestions to improve the tics, based on the reported cases.
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Cite this article as:
B. Centorino Michael, Catalano Glenn and C. Catalano Maria, Lamotrigine Induced Whole Body Tics: A Case Report and Literature Review, Current Drug Safety 2016; 11 (2) . https://dx.doi.org/10.2174/1574886311207040269
DOI https://dx.doi.org/10.2174/1574886311207040269 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
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