Abstract
Bioorthogonal reactions have been widely used on live-cell labeling, animal tissue imaging, drug delivery, and biomaterials in the recent ten years. Tetrazine bioorthogonal chemistry is not only orthogonal with biological system, other click chemistry and traditional polymer chemistry, but also has superb kinetics, generates biocompatibility products, and proceeds under mild reaction condition. All these features enable tetrazine bioorthogonal chemistry to be widely applied to polymer and biomaterial science. Recently there are many exciting accomplishments. This chemistry can act as an ideal method for polymer and nanoparticle modification, a desired vehicle for nanoparticles in vivo delivery, new polymerization strategy, and novel hydrogel formation platform. In this review, we introduce recent advancements in biomaterials based on tetrazine bioorthogonal chemistry.
Keywords: Bioorthogonal chemistry, tetrazine, polymer, biomaterials, nanoparticles.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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