Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

Title:Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

Volume: 15 Issue: 9

Author(s): O. Florey, S. E. Kim and M. Overholtzer

Affiliation:

Keywords: Cell-in-cell, entosis, entotic cell death, cannibalism, phagocytosis, engulfment, autophagy, LAP, cell competition.

Abstract: Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.

Cite this article as:

Florey O., Kim E. S. and Overholtzer M., Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death, Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/1566524015666151026100042