摘要
Entosis是 cell-in-cell形成机制,目标是吸收上皮细胞培养的活细胞和人类肿瘤。Entotic 细胞为控制自己不被吞没,入侵到宿主Rho-GTP酶肌凝蛋白的方式。虽然Entotic 细胞内化而活着,大多数最终接受non-apoptotic的细胞死亡形式,称为Entotic 细胞死亡,通过自噬和溶酶体的蛋白质执行non-cell-autonomously。这里我们回顾当前entosis和entotic 细胞死亡的理解和讨论这个过程在癌症的潜在作用。
关键词: Cell-in-cell
Current Molecular Medicine
Title:Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death
Volume: 15 Issue: 9
Author(s): O. Florey, S. E. Kim and M. Overholtzer
Affiliation:
关键词: Cell-in-cell
摘要: Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
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Cite this article as:
O. Florey, S. E. Kim and M. Overholtzer , Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death, Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/1566524015666151026100042
DOI https://dx.doi.org/10.2174/1566524015666151026100042 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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