Synthesis, Anti-tumor Activity and Odd–even Effect of Simple Isatin Derivatives

Title:Synthesis, Anti-tumor Activity and Odd–even Effect of Simple Isatin Derivatives

Volume: 12 Issue: 10

Author(s): Gang Chen, Xiaojiang Hao, Ye Wang and Shuzhen Mu

Affiliation:

Keywords: Isatin, derivative, synthesis, anti-tumor, neuro-protection, even-odd effect

Abstract: In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship.

Cite this article as:

Chen Gang, Hao Xiaojiang, Wang Ye and Mu Shuzhen, Synthesis, Anti-tumor Activity and Odd–even Effect of Simple Isatin Derivatives, Letters in Drug Design & Discovery 2015; 12 (10) . https://dx.doi.org/10.2174/157018081210151012120940

DOI https://dx.doi.org/10.2174/157018081210151012120940	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X