A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery

Title:A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery

Volume: 22 Issue: 38

Author(s): Syahrul Imran, Muhammad Taha and Nor Hadiani Ismail

Affiliation:

Keywords: Anticancer, anti-inflammation, bisindolylmethane, heterocycles, indole, pharmacological activities.

Abstract: Bisindolylmethane and its derivatives are pharmacologically active and applicable in the field of pharmaceutical chemistry. Bisindolylmethanes have a variety of biological activities such as antihyperglycemic, antiinflammatory, antibacterial, anticancer, and antileishmanial activities, including enzyme inhibition activity. They play a crucial role in many diseases especially anticancer activity. Modifying their structure had proven to be useful in the search of new therapeutic agents. Extensive research carried out on bisindolylmethane and its derivatives shows that they are pharmacologically significant. The present review focuses on the pharmacological profile of bisindolylmethane derivatives. This review includes the current literature with an update of research findings as well as the perspectives that they hold for future research.

Cite this article as:

Imran Syahrul, Taha Muhammad and Ismail Hadiani Nor, A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery, Current Medicinal Chemistry 2015; 22 (38) . https://dx.doi.org/10.2174/0929867322666151006093930