摘要
二吲哚基甲烷及其衍生物在药物化学领域具有药理活性和应用。二吲哚甲烷有多种生物活性,如降血糖、抗炎、抗菌、抗癌、和抗利什曼虫药作用,包括酶的抑制活性。它们在许多疾病尤其是抗癌活性中起着关键作用。在寻找新的治疗药物方面,修改它们的结构已被证明是有用的。二吲哚基甲烷及其衍生物药理开展的广泛研究显著的表明了此观点。本次审查的重点是二吲哚基甲烷衍生物的药理作用。这篇综述包括研究结果更新的近期文献,以及他们对未来的研究观点。
关键词: 抗癌,抗炎,二吲哚基甲烷,杂环化合物,吲哚,药理活动。
Current Medicinal Chemistry
Title:A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery
Volume: 22 Issue: 38
Author(s): Syahrul Imran, Muhammad Taha and Nor Hadiani Ismail
Affiliation:
关键词: 抗癌,抗炎,二吲哚基甲烷,杂环化合物,吲哚,药理活动。
摘要: Bisindolylmethane and its derivatives are pharmacologically active and applicable in the field of pharmaceutical chemistry. Bisindolylmethanes have a variety of biological activities such as antihyperglycemic, antiinflammatory, antibacterial, anticancer, and antileishmanial activities, including enzyme inhibition activity. They play a crucial role in many diseases especially anticancer activity. Modifying their structure had proven to be useful in the search of new therapeutic agents. Extensive research carried out on bisindolylmethane and its derivatives shows that they are pharmacologically significant. The present review focuses on the pharmacological profile of bisindolylmethane derivatives. This review includes the current literature with an update of research findings as well as the perspectives that they hold for future research.
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Cite this article as:
Syahrul Imran, Muhammad Taha and Nor Hadiani Ismail , A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery, Current Medicinal Chemistry 2015; 22 (38) . https://dx.doi.org/10.2174/0929867322666151006093930
DOI https://dx.doi.org/10.2174/0929867322666151006093930 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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