Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759)

Title:Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759)

Volume: 12 Issue: 10

Author(s): Phan Van Kiem, Nguyen Thi Viet Thanh, Dan Thi Thuy Hang, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Pham Hai Yen, Hoang Le Tuan Anh, Bui Huu Tai, Do Thi Thao and Chau Van Minh

Affiliation:

Keywords: Brominated lipid, cytotoxic, Haliclona oculata, steroid.

Abstract: Using various chromatography methods, five steroids and two brominated lipids (1-7), 3β- hydroxy-5-cholenic acid methyl ester, stigmasta-5,24(28)-dien-3β,29-diol, 24-methylenecholest-4-en- 3β,6β-diol, cholest-5-en-3β,7β-diol, 24-vinylcholest-5-en-3β,24-diol, xestospongiene A, and xestospongiene J, respectively, were isolated from the methanol extract of Vietnamese marine sponge Haliclona oculata (Linnaeus, 1759). Their structures were elucidated by 1D-, 2D-NMR, and ESI-MS spectra and in comparison with those reported in the literature. Compounds 1-4, 6, and 7 were reported from Chalinidae family for the first time. In addition, all compounds were evaluated for eight human cancer cell lines as HepG-2, KB, LU-1, MCF-7, LNCaP, HL- 60, SK-Mel2, and PC-3. As shown in results, compound 2 showed significant cytotoxic activities on KB and LU-1 cancer cell lines with the IC50 values ranging from 8.74 to 9.32 μM.

Cite this article as:

Kiem Van Phan, Thanh Thi Viet Nguyen, Hang Thi Thuy Dan, Cuc Thi Nguyen, Nhiem Xuan Nguyen, Yen Hai Pham, Anh Le Tuan Hoang, Tai Huu Bui, Thao Thi Do and Minh Van Chau, Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759), Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612999150923120855