Abstract
Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review compiles examples of novel synthetic compounds, which could be used as templates for developing novel drugs for the treatment of Cryptococcus infections.
Keywords: Antifungal, azole, cryptococcosis, Cryptococcus, heterocycles, natural product derivatives, peptide, phospholipidic compounds.
Graphical Abstract
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