Abstract
Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness rather than the level of consciousness. Most dementia is senile dementia, accounting for the majority of dementia. The most important and common form of senile dementia is refractory dementia, which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists. Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range of pharmacological effects. studies in recent years have also found that berberine can additionally treat senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
Keywords: Berberine, Senile dementia, Vascular dementia, Alzheimer's disease, Multi-target.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:The Role of Berberine in the Multi-Target Treatment of Senile Dementia
Volume: 16 Issue: 8
Author(s): Min Huang, Siyan Chen, Yubin Liang and Yi Guo
Affiliation:
Keywords: Berberine, Senile dementia, Vascular dementia, Alzheimer's disease, Multi-target.
Abstract: Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness rather than the level of consciousness. Most dementia is senile dementia, accounting for the majority of dementia. The most important and common form of senile dementia is refractory dementia, which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists. Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range of pharmacological effects. studies in recent years have also found that berberine can additionally treat senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
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Cite this article as:
Huang Min, Chen Siyan, Liang Yubin and Guo Yi, The Role of Berberine in the Multi-Target Treatment of Senile Dementia, Current Topics in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1568026615666150827095433
DOI https://dx.doi.org/10.2174/1568026615666150827095433 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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