Abstract
Alzheimer’s disease is a devastating and invariably fatal neurodegenerative brain disorder with no cure. AD is characterized by two pathological protein deposits, the senile plaques composed mainly of amyloid-β (Aβ) peptide and the neurofibrillary tangles which are bundles of paired helical filaments (PHF) of protein tau. In addition, oxidative stress, disorders in signal transduction and metal ions dyshomeostasis also play significant roles in the development of AD. A large body of studies suggests that selenium (Se), either as Se-containing compounds or as selenoproteins, may be beneficial in reducing Alzheimer’s pathology. Se is involved in most of the molecular pathways that are important in the progression of AD. We reviewed the literature regarding Se and AD and discussed the roles and mechanisms of Se in AD, as well as the potential of Se in AD prevention.
Keywords: Alzheimer’s disease (AD), Amyloid-β, Metal, Oxidative stress, Selenium (Se), Selenoprotein, Signal transduction, Tau
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Potential Roles of Selenium and Selenoproteins in the Prevention of Alzheimer's Disease
Volume: 16 Issue: 8
Author(s): Xiubo Du, Chao Wang and Qiong Liu
Affiliation:
Keywords: Alzheimer’s disease (AD), Amyloid-β, Metal, Oxidative stress, Selenium (Se), Selenoprotein, Signal transduction, Tau
Abstract: Alzheimer’s disease is a devastating and invariably fatal neurodegenerative brain disorder with no cure. AD is characterized by two pathological protein deposits, the senile plaques composed mainly of amyloid-β (Aβ) peptide and the neurofibrillary tangles which are bundles of paired helical filaments (PHF) of protein tau. In addition, oxidative stress, disorders in signal transduction and metal ions dyshomeostasis also play significant roles in the development of AD. A large body of studies suggests that selenium (Se), either as Se-containing compounds or as selenoproteins, may be beneficial in reducing Alzheimer’s pathology. Se is involved in most of the molecular pathways that are important in the progression of AD. We reviewed the literature regarding Se and AD and discussed the roles and mechanisms of Se in AD, as well as the potential of Se in AD prevention.
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Cite this article as:
Du Xiubo, Wang Chao and Liu Qiong, Potential Roles of Selenium and Selenoproteins in the Prevention of Alzheimer's Disease, Current Topics in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1568026615666150827094936
DOI https://dx.doi.org/10.2174/1568026615666150827094936 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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