Abstract
Mitochondrial dysfunction and neuroinflammation occur in Alzheimer’s disease (AD). The causes of these pathologic lesions remain uncertain, but links between these phenomena are increasingly recognized. In this review, we discuss data that indicate mitochondria or mitochondrial components may contribute to neuroinflammation. While mitochondrial dysfunction could cause neuroinflammation, neuroinflammation could also cause mitochondrial dysfunction. However, based on the systemic nature of AD mitochondrial dysfunction as well as data from experiments we discuss, the former possibility is perhaps more likely. If correct, then manipulation of mitochondria, either directly or through manipulations of bioenergetic pathways, could prove effective in reducing metabolic dysfunction and neuroinflammation in AD patients. We also review some potential approaches through which such manipulations may be achieved.
Keywords: Alzheimer’s disease, Bioenergetics, Damage associated molecular pattern, Inflammation, Mitochondria.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease
Volume: 16 Issue: 8
Author(s): Heather M. Wilkins and Russell H. Swerdlow
Affiliation:
Keywords: Alzheimer’s disease, Bioenergetics, Damage associated molecular pattern, Inflammation, Mitochondria.
Abstract: Mitochondrial dysfunction and neuroinflammation occur in Alzheimer’s disease (AD). The causes of these pathologic lesions remain uncertain, but links between these phenomena are increasingly recognized. In this review, we discuss data that indicate mitochondria or mitochondrial components may contribute to neuroinflammation. While mitochondrial dysfunction could cause neuroinflammation, neuroinflammation could also cause mitochondrial dysfunction. However, based on the systemic nature of AD mitochondrial dysfunction as well as data from experiments we discuss, the former possibility is perhaps more likely. If correct, then manipulation of mitochondria, either directly or through manipulations of bioenergetic pathways, could prove effective in reducing metabolic dysfunction and neuroinflammation in AD patients. We also review some potential approaches through which such manipulations may be achieved.
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Cite this article as:
Wilkins M. Heather and Swerdlow H. Russell, Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease, Current Topics in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1568026615666150827095102
DOI https://dx.doi.org/10.2174/1568026615666150827095102 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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