An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa

Title:An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa

Volume: 13 Issue: 6

Author(s): Shu-ichi Kojima, Atsushi Tohei, Masashi Ikeda and Naohiko Anzai

Affiliation:

Keywords: Colon, enterochromaffin cells, 5-HT (5-hydroxytryptamine, serotonin) release, melatonin, peptide YY, tachykinins, NK₂ and NK₃ receptors, Y₁ receptors.

Abstract: 5-Hydroxytryptamine (5-HT) released from colonic mucosal enterochromaffin (EC) cells is a major signaling molecule, which participates in the pathophysiological regulation of colonic functions in gut disorder including irritable bowel syndrome (IBS), but the endogenous modulator system for the 5-HT release is not yet well elucidated. Our in vitro studies in guinea-pig colon have indicated that the cascade pathway of neuronal tachykinergic NK₃ receptors and NK₂ receptors on peptide YY (PYY)-containing endocrine L cells represents an endogenous modulator system for 5-HT release from EC cells and that melatonin, endogenous tachykinins and PYY play important roles in modulation of the release of 5-HT from EC cells via the endogenous NK₂/NK₃ receptor cascade system. This review aims at examining the potential role of the endogenous tachykinergic NK₂/NK₃ receptor cascade system controlling the release of 5-HT from EC cells, with special attention being paid to the pathophysiology of gut disorders including IBS.

Cite this article as:

Kojima Shu-ichi, Tohei Atsushi, Ikeda Masashi and Anzai Naohiko, An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa, Current Neuropharmacology 2015; 13 (6) . https://dx.doi.org/10.2174/1570159X13666150825220524