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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Decreasing Systemic Toxicity Via Transdermal Delivery of Anticancer Drugs

Author(s): Jia-You Fang, Pei-Feng Liu and Chun-Ming Huang

Volume 9, Issue 7, 2008

Page: [592 - 597] Pages: 6

DOI: 10.2174/138920008785821693

Price: $65

Abstract

When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity. In this review, we summarize various advanced technologies for improving anticancer drug delivery via the skin. This technology is discussed in the context of three anticancer drugs, 5-fluorouracil (5-FU), methotrexate (MTX) and 5-aminolevulinic acid (5-ALA). The use of a erbium:YAG (Er:YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review.

Keywords: Toxicity, transdermal delivery, laser, anticancer drugs


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