Abstract
A3 adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A3AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N6 and C-2 position of the adenosine moiety has led to the discovery of some of the most efficacious A3AR ligands. This review is an account of the development of 4'-thionucleosides as A3AR agonists and antagonists by various chemical modifications on the thionucleoside template.
Keywords: A3 adenosine receptor, agonist, antagonist, 4’-thionucleoside, structure-activity relationship.
Graphical Abstract
Current Organic Chemistry
Title:4'-Thionucleosides as Potent and Selective A3 Adenosine Receptor Ligands
Volume: 20 Issue: 8
Author(s): Pramod K. Sahu, Siddhi D. Naik, Sofia Mehdi and Lak S. Jeong
Affiliation:
Keywords: A3 adenosine receptor, agonist, antagonist, 4’-thionucleoside, structure-activity relationship.
Abstract: A3 adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A3AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N6 and C-2 position of the adenosine moiety has led to the discovery of some of the most efficacious A3AR ligands. This review is an account of the development of 4'-thionucleosides as A3AR agonists and antagonists by various chemical modifications on the thionucleoside template.
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Cite this article as:
K. Sahu Pramod, D. Naik Siddhi, Mehdi Sofia and S. Jeong Lak, 4'-Thionucleosides as Potent and Selective A3 Adenosine Receptor Ligands, Current Organic Chemistry 2016; 20 (8) . https://dx.doi.org/10.2174/1385272819666150804000511
DOI https://dx.doi.org/10.2174/1385272819666150804000511 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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