Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives

Title:Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives

Volume: 3 Issue: 2

Author(s): Mayuri A. Borad, Manoj N. Bhoi, Darshita M. Patel and Hitesh D. Patel

Affiliation:

Keywords: CuCl₂, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.

Abstract: A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl₂ catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.

Cite this article as:

Borad A. Mayuri, Bhoi N. Manoj, Patel M. Darshita and Patel D. Hitesh, Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives, Current Microwave Chemistry 2016; 3 (2) . https://dx.doi.org/10.2174/2213335602666150722232613