Abstract
During the last years significant efforts have been made to discover compounds with inhibitory activity of quorum-sensing systems, which could represent an anti-pathogenic strategy, since they will inhibit the coordinated expression of virulence determinants, without interfering with bacterial growth, being less likely to generate resistance. The present study is reviewing the main types of quorum sensing inhibitors known to date, that manifest the potential to be used as anti-virulence drugs for the treatment of infections with multidrug resistant P. aeruginosa strains, and describes a new strategy of virulence attenuation based on organic acids produced by probiotic strains, which have been proved to influence in sub-inhibitory (sI) grown concentrations the QS genes expression in P. aeruginosa multidrug resistant strains, proving that the organic acids secreted by probiotics could act as quorum sensing inhibitors.
Keywords: Anti-pathogenic strategy, Multidrug resistance, Quorum-sensing inhibitors, P. aeruginosa, probiotics
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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