Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture

Title:Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture

Volume: 12 Issue: 4

Author(s): Yogesh Kumar Tailor, Sarita Khandelwal, Hemant Kumar Jain and Mahendra Kumar

Affiliation:

Keywords: Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.

Abstract: Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.

Cite this article as:

Kumar Tailor Yogesh, Khandelwal Sarita, Kumar Jain Hemant and Kumar Mahendra, Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture, Current Organic Synthesis 2015; 12 (4) . https://dx.doi.org/10.2174/157017941204150522190425