RNA G-Quadruplex: The New Potential Targets for Therapy

Title:RNA G-Quadruplex: The New Potential Targets for Therapy

Volume: 15 Issue: 19

Author(s): Shi-Ke Wang, Yue Wu and Tian-Miao Ou

Affiliation:

Keywords: G-quadruplex, RNA, Drug targets, Biological function, DNA.

Abstract: Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA Gquadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.

Cite this article as:

Wang Shi-Ke, Wu Yue and Ou Tian-Miao, RNA G-Quadruplex: The New Potential Targets for Therapy, Current Topics in Medicinal Chemistry 2015; 15 (19) . https://dx.doi.org/10.2174/1568026615666150515145733