Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds

Title:Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds

Volume: 3 Issue: 2

Author(s): Avik Kumar Bagdi, Dhiman Kundu, Adinath Majee and Alakananda Hajra

Affiliation:

Keywords: Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.

Abstract: An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.

Cite this article as:

Bagdi Kumar Avik, Kundu Dhiman, Majee Adinath and Hajra Alakananda, Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150414201734