Abstract
Snake toxins consist of different pharmacologically lively peptides and proteins. These hemorrhagic proteins are metalloproteinases with molecular weights between 20 to 100 kDa. SVMPs are zinc-dependent types and with a multidomain association. SVMPs consist of only the proteinase type of domain, while some contain other types such as cysteine, lectin and disintegrins. They are analogous with both MMP and ADAMs group. SVMPs are 30% of the total protein of snake’s venoms. Hemorrhagic activity and the stimulation of local and systemic bleeding generally are due to SVMPs. Necrosis, skin damage, inflammatory reaction, arthritis and are responsible for causing paralysis. These proteinase types also hold diverse functions such as the disruption of hemostasis, platelet aggregation and pro-inflammatory activities. This short review focuses on the most prominent effects induced by SVMPs.
Keywords: ADAMs, hemorrhagic proteins, inflammation, MMP, SVMPs.
Graphical Abstract
Current Chemical Biology
Title:Snake Venom Metalloproteinases: Structure, Mechanism and Induced Diseases
Volume: 8 Issue: 2
Author(s): Atul Kaushik, Anghesom Ambesajir and Jeevan J. Kaushik
Affiliation:
Keywords: ADAMs, hemorrhagic proteins, inflammation, MMP, SVMPs.
Abstract: Snake toxins consist of different pharmacologically lively peptides and proteins. These hemorrhagic proteins are metalloproteinases with molecular weights between 20 to 100 kDa. SVMPs are zinc-dependent types and with a multidomain association. SVMPs consist of only the proteinase type of domain, while some contain other types such as cysteine, lectin and disintegrins. They are analogous with both MMP and ADAMs group. SVMPs are 30% of the total protein of snake’s venoms. Hemorrhagic activity and the stimulation of local and systemic bleeding generally are due to SVMPs. Necrosis, skin damage, inflammatory reaction, arthritis and are responsible for causing paralysis. These proteinase types also hold diverse functions such as the disruption of hemostasis, platelet aggregation and pro-inflammatory activities. This short review focuses on the most prominent effects induced by SVMPs.
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Cite this article as:
Kaushik Atul, Ambesajir Anghesom and Kaushik J. Jeevan, Snake Venom Metalloproteinases: Structure, Mechanism and Induced Diseases, Current Chemical Biology 2014; 8 (2) . https://dx.doi.org/10.2174/221279680802150406152316
DOI https://dx.doi.org/10.2174/221279680802150406152316 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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