A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation

Title:A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation

Volume: 3 Issue: 1

Author(s): Kinjal D. Patel, Rajesh H. Vekariya and Hitesh D. Patel

Affiliation:

Keywords: Catalyst free one pot reaction, microwave irradiation, multi component reaction, oxadiazole, solvent.

Abstract: A convenient one-pot, multi-component and solvent free procedure for the preparation of substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives in high yields with high purity. All synthesized compounds were characterized by FT-IR, proton and carbon NMR, mass spectroscopy and elemental analysis. A possible mechanism is proposed for the cyclodesulfurization based on the results of this study.

Cite this article as:

Patel D. Kinjal, Vekariya H. Rajesh and Patel D. Hitesh, A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150324233632