Synthesis, Spectral Characterization and Anticancer Activity of New 2,3,6- Substituted Quinazolin-4(3H)-one Derivatives

Title:Synthesis, Spectral Characterization and Anticancer Activity of New 2,3,6- Substituted Quinazolin-4(3H)-one Derivatives

Volume: 12 Issue: 6

Author(s): Peddakonda Ramesh, Doddaga Srinivasulu, Polireddy Kishore, Valasani Koteswara Rao and Muttana Vijaya Bhaskara Reddy

Affiliation:

Keywords: Anthranilic acid, Pd catalyst, piperazine, quinazolin-4(3H)-ones, anticancer activity, pancreatic cancer cell line-1 (PANC-1).

Abstract: A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 µM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth of PANC-1 cells by >75% and remaining compounds showed moderate anticancer activity. The structural characterization of the synthesized compounds was elucidated by 1H & 13C NMR, LC-MS, FT-IR and elemental analysis. As potential anti-tumor agents, these new derivatives show promise for further research.

Cite this article as:

Ramesh Peddakonda, Srinivasulu Doddaga, Kishore Polireddy, Rao Koteswara Valasani and Reddy Vijaya Bhaskara Muttana, Synthesis, Spectral Characterization and Anticancer Activity of New 2,3,6- Substituted Quinazolin-4(3H)-one Derivatives, Letters in Organic Chemistry 2015; 12 (6) . https://dx.doi.org/10.2174/1570178612666150320233833