One-Pot Syntheses of 1H-Pyrazolo[1,2-B]Phthalazine-5,10-Diones and 2-H-Indazolo[2,1-B]Phthalazine-1,6,11(13-H)-Triones in Water by Auto Catalysis

Title:One-Pot Syntheses of 1H-Pyrazolo[1,2-B]Phthalazine-5,10-Diones and 2-H-Indazolo[2,1-B]Phthalazine-1,6,11(13-H)-Triones in Water by Auto Catalysis

Volume: 12 Issue: 6

Author(s): Y. Dathu Reddy, P. Praveen Kumar, B. Rama Devi, Venkata Ramana Reddy and P. K. Dubey

Affiliation:

Keywords: Water, phthaloyl dichloride, one-pot syntheses, green syntheses.

Abstract: One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1) , hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water for 1-1.5 h by in-situ generation of HCl as a catalyst. These reactions have an easy workup, provide excellent yields, and use water as the solvent.

Cite this article as:

Reddy Dathu Y., Kumar Praveen P., Devi Rama B., Reddy Ramana Venkata and Dubey K. P., One-Pot Syntheses of 1H-Pyrazolo[1,2-B]Phthalazine-5,10-Diones and 2-H-Indazolo[2,1-B]Phthalazine-1,6,11(13-H)-Triones in Water by Auto Catalysis, Letters in Organic Chemistry 2015; 12 (6) . https://dx.doi.org/10.2174/1570178612666150415235453