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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

UHPLC/Q-TOF-MS Technique: Introduction and Applications

Author(s): Hamid Khan and Javed Ali

Volume 12, Issue 6, 2015

Page: [371 - 378] Pages: 8

DOI: 10.2174/1570178612666150331204147

Price: $65

Abstract

The ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) technique is a new approach in the chromatographic separations and has been successfully employed for fast, high resolution separations with required sensitivity. The TOF-MS is helpful in the structure elucidation and identification of fragmentation patterns of the compounds. This review provides the brief introduction and applications of UHPLC/Q-TOF-MS with examples of some of the most advanced work in the pharmaceutical analysis.

Keywords: UHPLC/Q-TOF-MS, applications, identification, determination, pharmaceutical analysis.

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