N-Aryl-5-aminopyrazole: A Versatile Architecture in Medicinal Chemistry

Title:N-Aryl-5-aminopyrazole: A Versatile Architecture in Medicinal Chemistry

Volume: 15 Issue: 4

Author(s): Maura Marinozzi, Gloria Marcelli and Andrea Carotti

Affiliation:

Keywords: Biologically active compounds, nitrogen-heterocycle, pyrazole, privileged structure.

Abstract: N-Aryl-5-aminopyrazole represents a key structural motif in a plethora of biologically active molecules endowed with a wide spectrum of pharmacological properties. Accordingly, this scaffold can be certainly included in the category of a privileged structure. As an example, N-aryl-5- aminopyrazole along with its 5-ureido derivatives are recurrent scaffolds in the field of inhibition of the different members of mitogen-activated protein kinases (MAPKs). Over the past recent years a large number of papers highlighting the design, synthesis and biological evaluation of different classes of N-aryl-5-aminopyrazole-containing compounds have been reported in the literature, but a review on this topic is still missing. With the aim to fill this gap, the present review article focuses on the recent developments (1995-mid2014) on the application of the N-aryl-5-aminopyrazole-based compounds in different therapeutic fields, with a particular attention to the design and structure-activity relationships (SAR) aspects of each class of compounds.

Cite this article as:

Marinozzi Maura, Marcelli Gloria and Carotti Andrea, N-Aryl-5-aminopyrazole: A Versatile Architecture in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2015; 15 (4) . https://dx.doi.org/10.2174/1389557515666150312154536