Abstract
Although it is generally accepted that the abuse-related effects of amphetamines and cocaine result from the activation of the brain dopaminergic (DA) system, the psychostimulants also alter other neurotransmitter systems. In particular, they increase extracellular levels of norepinephrine (NE) and serotonin by inhibiting respective plasma membrane transporters and/or inducing release. The present review will discuss the preclinical findings on the effects of the NE system modulation (lesions, pharmacological and genetic approaches) on behaviors (locomotor hyperactivity, behavioral sensitization, modification of intracranial self-stimulation, conditioned place preference, drug selfadministration, extinction/reinstatement of drug seeking behavior) related to the psychostimulant addiction.
Keywords: Amphetamine, behavioral sensitization, cocaine, conditioned place preference, drug self-administration, intracranial self-stimulation, locomotor activity, norepinephrine.
Graphical Abstract
Current Neuropharmacology
Title:The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction
Volume: 13 Issue: 3
Author(s): Magdalena Zaniewska, Małgorzata Filip and Edmund Przegalinski
Affiliation:
Keywords: Amphetamine, behavioral sensitization, cocaine, conditioned place preference, drug self-administration, intracranial self-stimulation, locomotor activity, norepinephrine.
Abstract: Although it is generally accepted that the abuse-related effects of amphetamines and cocaine result from the activation of the brain dopaminergic (DA) system, the psychostimulants also alter other neurotransmitter systems. In particular, they increase extracellular levels of norepinephrine (NE) and serotonin by inhibiting respective plasma membrane transporters and/or inducing release. The present review will discuss the preclinical findings on the effects of the NE system modulation (lesions, pharmacological and genetic approaches) on behaviors (locomotor hyperactivity, behavioral sensitization, modification of intracranial self-stimulation, conditioned place preference, drug selfadministration, extinction/reinstatement of drug seeking behavior) related to the psychostimulant addiction.
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Cite this article as:
Zaniewska Magdalena, Filip Małgorzata and Przegalinski Edmund, The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction, Current Neuropharmacology 2015; 13 (3) . https://dx.doi.org/10.2174/1570159X13666150121225659
DOI https://dx.doi.org/10.2174/1570159X13666150121225659 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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