Abstract
The aim of the present article is to provide a summary of the epigenetic modifications that might occur in children exposed to heavy metals pollutants. It is known that children are more susceptible to environmental pollutants, because their detoxification enzymes are less competent, and this may lead to alterations in chromatin structure or of DNA causing, in turn, epigenetic modifications. Little is currently known about the long-term effects of these changes when occur early in childhood, nonetheless there are ethics and practical concerns that make the assessment of DNA modifications difficult to perform in large-scale.
Keywords: Epigenetic, Arsenic, Cadmium, Heavy metals, Children.
Graphical Abstract
Current Genomics
Title:Epigenetic Modifications Due to Heavy Metals Exposure in Children Living in Polluted Areas
Volume: 15 Issue: 6
Author(s): Alessandra Bitto, Gabriele Pizzino, Natasha Irrera, Federica Galfo and Francesco Squadrito
Affiliation:
Keywords: Epigenetic, Arsenic, Cadmium, Heavy metals, Children.
Abstract: The aim of the present article is to provide a summary of the epigenetic modifications that might occur in children exposed to heavy metals pollutants. It is known that children are more susceptible to environmental pollutants, because their detoxification enzymes are less competent, and this may lead to alterations in chromatin structure or of DNA causing, in turn, epigenetic modifications. Little is currently known about the long-term effects of these changes when occur early in childhood, nonetheless there are ethics and practical concerns that make the assessment of DNA modifications difficult to perform in large-scale.
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Cite this article as:
Bitto Alessandra, Pizzino Gabriele, Irrera Natasha, Galfo Federica and Squadrito Francesco, Epigenetic Modifications Due to Heavy Metals Exposure in Children Living in Polluted Areas, Current Genomics 2014; 15 (6) . https://dx.doi.org/10.2174/138920291506150106153336
DOI https://dx.doi.org/10.2174/138920291506150106153336 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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