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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Microwave-assisted Synthesis of HYNIC Protected Analogue for 99mTc Labeled Antibody

Author(s): Maria F. Garcia, Victoria Calzada, Ximena Camacho, Enzo Goicochea, Juan Pablo Gambini, Thomas P. Quinn, Williams Porcal and Pablo Cabral

Volume 7, Issue 2, 2014

Page: [84 - 90] Pages: 7

DOI: 10.2174/1874471007666141128160449

Price: $65

Abstract

We described herein a simple and efficient microwave assisted synthesis of HYNIC analogues. Two different activated esters of HYNIC, the hydrazine protected with a trifluoroacetyl group (5) and the free hydrazine (6) were conjugated to the monoclonal antibody Nimotuzumab. Technetium-99m radiolabeling of Nimotuzumab was achieved with high efficiency using 5 and 6 derivates. The NHS-HYNIC-Tfa derivate allowed better labeling yields during longer times of preservation of the conjugated antibody.

Keywords: 99m-technetium, HYNIC, microwave-assisted, nimotuzumab, trifluoroacetyl.


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