Platelet Inhibition Agents: Current and Future P2Y12 Receptor Antagonists

Title:Platelet Inhibition Agents: Current and Future P2Y12 Receptor Antagonists

Volume: 13 Issue: 5

Author(s): Jie Tang, Mu-Peng Li, Hong-Hao Zhou and Xiao-Ping Chen

Affiliation:

Keywords: Antiplatelet, clopidogrel, cangrelor, elinogrel, P2Y₁₂ receptor, prasugrel, ticagrelor.

Abstract: Percutaneous coronary intervention is widely used to reduce the risk of death or cardiovascular events in patients with acute coronary syndromes. Dual antiplatelet treatment with aspirin and clopidogrel has become routine practice to prevent thrombotic events after coronary surgery. Despite advances of significant reduction of thrombotic complications in this adjunctive therapy, major adverse cardiovascular events still occur, suggesting the need for development of novel antiplatelet agents that act as superior alternatives to current standard regimen. Recently developed antiplatelet agents (prasugrel, ticagrelor, cangrelor and elinogrel) efficiently antagonize P2Y₁₂ receptor, a key platelet activating signaling pathway, and thereby inhibit aggregation induced by mediators such as ADP, collagen, thrombin and TXA2. We provide an evidence-based review on the pharmacological and clinical performance of clopidogrel and novel antiplatelet agents that antagonize P2Y₁₂ receptors.

Cite this article as:

Tang Jie, Li Mu-Peng, Zhou Hong-Hao and Chen Xiao-Ping, Platelet Inhibition Agents: Current and Future P2Y12 Receptor Antagonists, Current Vascular Pharmacology 2015; 13 (5) . https://dx.doi.org/10.2174/1570161112666141127162209