Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial

Title:Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial

Volume: 13 Issue: 4

Author(s): Guo-Xin Li, Yong-Yan Wang, Chun-Ti Shen, Zhong Wang, Lei Zhang, Qi-guang Chen, Song-Shan Liu, Shu-Rong Liu, Zhuo-Ming Li, Xiao-Feng Wang, Jie Xue, Dong-Hai Wang, Bo Dong, Li-Ying Wang, Xi-Yan Yang, Xiang-Ling Liu, Si-Yuan Hu, Zhi-Wei Jing, Li-Ya Su, Hong-Li Wu, Bi-Wei Chen, Ya-Nan Yu, Wei Lu, Jun Liu and Jian-Yuan Tang

Affiliation:

Keywords: Stable angina pectoris, similarity degree analysis, nonlinear mixed effect model, treatment effectiveness.

Abstract: Objective: To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment.

Methods: Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling (NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest, palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on Days 0, 14, 28, 42, and 56.

Results: Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group.

Conclusion: Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic variation of SAP may be determined, to improve the development and modification of treatment regimens.

Cite this article as:

Li Guo-Xin, Wang Yong-Yan, Shen Chun-Ti, Wang Zhong, Zhang Lei, Chen Qi-guang, Liu Song-Shan, Liu Shu-Rong, Li Zhuo-Ming, Wang Xiao-Feng, Xue Jie, Wang Dong-Hai, Dong Bo, Wang Li-Ying, Yang Xi-Yan, Liu Xiang-Ling, Hu Si-Yuan, Jing Zhi-Wei, Su Li-Ya, Wu Hong-Li, Chen Bi-Wei, Yu Ya-Nan, Lu Wei, Liu Jun and Tang Jian-Yuan, Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial, Current Vascular Pharmacology 2015; 13 (4) . https://dx.doi.org/10.2174/1570161112666141014151858