Generic placeholder image

Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Screening of Indigenously Isolated Fungi for Lovastatin Production and Its in vivo Evaluation

Author(s): Sadia Javed, Shazia A. Bukhari, Iram Zovia and Munazzah Meraj

Volume 15, Issue 4, 2014

Page: [422 - 427] Pages: 6

DOI: 10.2174/1389201015666140528152138

Price: $65

conference banner
Abstract

Seven indigenously isolated fungal strains (Aspergillus niger, Aspergillus flavus, Aspergillus terreus, Penicillium citrinum, Penicillium notatum, Pleurotus ostreatus and Trichoderma viradae) were tested for their potential to produce cholesterol lowering drug lovastatin by using different agro-industrial wastes (Corn cobs, corn stover, banana stalk, wheat straw, wheat bran, bagasse) in submerged as well as solid state fermentation. Aspergillus terreus showed maximum production of 18.74 mg/100mL by wheat bran in solid state fermentation. The fermentation parameters (pH, temperature, Inoculum size, moisture contents and fermentation time) were also optimized for optimum production of lovastatin. It was found that Aspergillus terreus could produce 27.14 mg/100mL lovastatin under optimum condition of pH (6), temperature (30oC), Inoculum size (2mL), moisture contents (60%) and fermentation time (120hrs) in solid state fermentation. The optimized lovastatin was extracted from fermented broth and orally administered to rats. The hypocholesterolemic effect of fermented lovastatin was evaluated on serum ALT, AST, HDL-C, LDL-C, TG and TC level of rats. It was concluded from the study, fermented lovastatin effectively lower the cholesterol level of rats.

Keywords: Agro industrial wastes, cardiovascular, fungi, HMG-CoA reductase, hypercholesterolemia, lovastatin, solid state fermentation.

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy