One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions

Title:One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions

Volume: 17 Issue: 5

Author(s): Mona Hosseini-Sarvari and Fatemeh Moeini

Affiliation:

Keywords: Amine, propargylamine, three-component reactions, ZnO.

Abstract: In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A³-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.

Cite this article as:

Hosseini-Sarvari Mona and Moeini Fatemeh, One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions, Combinatorial Chemistry & High Throughput Screening 2014; 17 (5) . https://dx.doi.org/10.2174/1386207316666131217104925