Abstract
Molecular chaperones and the heat shock response play a major role in the maintenance of cellular homeostasis under various pathological conditions. In particular, their role is to regulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellarnetworks. Among variousheat shock proteins, Hsp32 also known as heme oxygenase-1 (HO-1), has demonstrated an important role in metabolic syndrome. In particular, the HO system seems to play a major role in the complex pathophysiological cascade involved in insulin resistance mechanisms, and adipocyte functions as measured by the release of important adipokynes. The aim of the present review is to point out the role of HO-1 in metabolic syndrome, and how to exploit its beneficial effects as a therapeutic strategy to prevent complicationsof andto improve insulin sensitivity.
Keywords: Metabolic syndrome, heme oxygenase, insulin sensitivity, adiponectin, heat shock proteins.
Current Pharmaceutical Design
Title:The Role of the Heme Oxygenase System in the Metabolic Syndrome
Volume: 20 Issue: 31
Author(s): Ignazio Barbagallo, Anna Nicolosi, Giorgio Calabrese, Sabrina David, Sebastiano Cimino, Massimo Madonia and Francesco Cappello
Affiliation:
Keywords: Metabolic syndrome, heme oxygenase, insulin sensitivity, adiponectin, heat shock proteins.
Abstract: Molecular chaperones and the heat shock response play a major role in the maintenance of cellular homeostasis under various pathological conditions. In particular, their role is to regulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellarnetworks. Among variousheat shock proteins, Hsp32 also known as heme oxygenase-1 (HO-1), has demonstrated an important role in metabolic syndrome. In particular, the HO system seems to play a major role in the complex pathophysiological cascade involved in insulin resistance mechanisms, and adipocyte functions as measured by the release of important adipokynes. The aim of the present review is to point out the role of HO-1 in metabolic syndrome, and how to exploit its beneficial effects as a therapeutic strategy to prevent complicationsof andto improve insulin sensitivity.
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Barbagallo Ignazio, Nicolosi Anna, Calabrese Giorgio, David Sabrina, Cimino Sebastiano, Madonia Massimo and Cappello Francesco, The Role of the Heme Oxygenase System in the Metabolic Syndrome, Current Pharmaceutical Design 2014; 20 (31) . https://dx.doi.org/10.2174/1381612819666131206103824
DOI https://dx.doi.org/10.2174/1381612819666131206103824 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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