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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Multicomponent 1,3-Dipolar Cycloaddition Reactions in the Construction of Hybrid Spiroheterocycles

Author(s): Natarajan Arumugam, Raju Suresh Kumar, Abdulrahman I. Almansour and Subbu Perumal

Volume 17, Issue 18, 2013

Page: [1929 - 1956] Pages: 28

DOI: 10.2174/13852728113179990091

Price: $65

Abstract

Spiroheterocyclic ring systems are attractive synthetic targets due to their interesting conformational features and their structural implications on their activity in biological systems. Consequently, a vast deal of research by synthetic organic as well as medicinal chemists pertains to the synthesis of these heterocycles employing diverse synthetic methodologies. Among them, one-pot multicomponent 1,3-cycloaddition reactions have emerged as preferred synthetic protocol in view of their convergence, atom economy, ecofriendliness, flexibility and facile automation. This review article focuses on the assembly of mono-, di- and multispiro heterocyclic hybrids via aforesaid synthetic methodologies with a variety of dipolarophiles.

Keywords: Multicomponent, 1, 3-Dipolar cycloadditions, Spiroheterocycles, Azomethine ylides and Nitrile oxides.


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