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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles

Author(s): Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez and Thierry Constantieux

Volume 17, Issue 18, 2013

Page: [1920 - 1928] Pages: 9

DOI: 10.2174/13852728113179990090

Abstract

This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3- dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.

Keywords: Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl compounds.


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